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PPh3-catalyzed intramolecular cyclization of hydroxypropargylamides: Synthesis of structurally diverse morpholinone derivatives

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Title PPh3-catalyzed intramolecular cyclization of hydroxypropargylamides: Synthesis of structurally diverse morpholinone derivatives
 
Creator Paira, Moumita
 
Subject Ugi four-component reaction (U-4CR)
post-Ugi transformations
6-exo-dig cyclization
morpholinone
hydroxypropargylamide
 
Description 1014-1024
The metal-free synthesis of substituted morpholinones through a sequential intramolecular post-Ugi cyclization strategy is
described. In the subsequent step, Ugi adducts hydroxy propargylamides derivatives undergo chemo- and regioselective 6-exo-dig
catalytic cyclization to afford O-cyclized products in the presence of triphenylphosphine. This sequence offers an engrossing
functionalized morpholinone scaffold involving moderate reaction conditions with broad substrate scope and moderate to good
yields.
 
Date 2022-09-19T09:48:50Z
2022-09-19T09:48:50Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60502
https://doi.org/10.56042/ijc.v61i9.59955
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]