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Novel pyrazole-pyridine containing 4-thiazolidinone hybrids: Design, synthesis and antimicrobial activity

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Title Novel pyrazole-pyridine containing 4-thiazolidinone hybrids: Design, synthesis and antimicrobial activity
 
Creator Desai, Nisheeth C
Jadeja, Dharmpalsinh J
 
Subject Pyrazole
Pyridine
4-thiazolidinone
Antibacterial
Antifungal
 
Description 1006-1013
The emergence of antimicrobial resistance (AMR) to currently available antimicrobial agents is a major source of
concern for scientists. Antibiotic treatment against numerous bacteria and fungus is no longer effective due to antimicrobial
resistance, as bacteria and fungi have developed to fight antibiotics and proven them ineffective or less efficient. Novel
antimicrobial drugs that are effective against resistant strains are desperately needed. In continuation to this, we have
designed and synthesized 4-thiazolidinone clubbed pyridine-pyrazole analogues (5a-5o) for the evaluation of antimicrobial
activity. The structures of the newly prepared compounds were analyzed and confirmed by using IR, 1H NMR, 13C NMR
and mass spectroscopy. Synthesized compounds are tested against various bacterial and fungal strains. Among the tested
compounds, compounds 5b, 5g and 5m (MIC value of 62.5 μg/mL) have exhibited potency against E. coli gram-negative
strain while compounds 5a, 5c, 5g, 5i and 5l (MIC = 250 μg/mL) were active against C. albicans fungal strain.
 
Date 2022-09-19T09:51:55Z
2022-09-19T09:51:55Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60503
https://doi.org/10.56042/ijc.v61i9.59848
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]