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Isolation and structure elucidation of novel compounds from stem of Dendrophthoe falcata

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Title Isolation and structure elucidation of novel compounds from stem of Dendrophthoe falcata
 
Creator Kumar, Sandeep
Prasad, Ashok K
Mehta, Shilpika Bali
 
Subject Dendrophthoe falcata
Loranthus falcatus
traditional medicinal use
plasticizer
flavonoid
 
Description 999-1005
Dendrophthoe falcata (syn. With Loranthus falcatus) has been widely used in Indian and other traditional medicine systems as a
therapeutic herb. Extensive pharmacological studies of leaf and stem extracts of D. falcata have shown significant biological
activities. In the present study, an attempt has been made to carry out the phytochemical investigation of the petroleum ether and
dichloromethane extract of the stem part of D. falcata. The isolation and identification of the possible bioactive phytochemicals of
this plant may lead towards the development of new pharmaceutical products. Using repeated coloumn chromatography,
preparative TLC and crystallization techniques, ten compounds have been isolated in pure form. On the basis of detailed spectral
studies they have been identified as di-iso-octylphthalate 1, nonadecan-1-ol 2, stigmast-4-en-3-one 3, stigmast-5-en-3β-ol 4,
stigmast-5,22-E-dien-3β-ol 5, 3β-hydroxylup-20(29)-en-28-oic acid 6, 3β-hydroxyolean-12-en-28-oic acid 7, 7-hydroxy-4',5,6-
trimethoxyflavone 8, 2,3-dihydro-4-hydroxy-3,6,9-trimethylnaphtho[1,8-bc]pyran-7,8-dione 9 and 4-hydroxy-3-methoxybenzoic
acid 10. Compounds 1, 4, 5, 7 and 10 have previously been reported from Dendrophthoe species. This is the first report of
compounds 2, 3, 6, 8 and 9 from Dendrophthoe species and the first report of 8 from a natural source. Further research work is
needed on these identified compounds to explore their usefulness in phytopharmaceutical products.
 
Date 2022-09-19T09:54:32Z
2022-09-19T09:54:32Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60504
https://doi.org/10.56042/ijc.v61i9.59556
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]