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Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

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Title Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents
 
Creator Chavan, Harshal
Shirodkar, Prutha
Mogal, Rajendra
Amrutkar, Sunil
 
Subject Thiosemicarbazide
1,2,4-triazole
antimicrobial activity
antifungal activity
anthelmintic activity
 
Description 994-998
Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for
antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide
and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium
followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids
are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized
compounds are in the range of 3.12-25 μg/mL.
 
Date 2022-09-19T10:01:38Z
2022-09-19T10:01:38Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60505
https://doi.org/10.56042/ijc.v61i9.66354
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]