Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents
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Title |
Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents
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Creator |
Chavan, Harshal
Shirodkar, Prutha Mogal, Rajendra Amrutkar, Sunil |
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Subject |
Thiosemicarbazide
1,2,4-triazole antimicrobial activity antifungal activity anthelmintic activity |
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Description |
994-998
Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL. |
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Date |
2022-09-19T10:01:38Z
2022-09-19T10:01:38Z 2022-09 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60505 https://doi.org/10.56042/ijc.v61i9.66354 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.61(09) [Sep 2022]
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