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Synthesis and characterisation of novel tetradentate Schiff base complexes: Biological evaluation exploring anticancer activity towards MCF 7 cell breast cancer lines with in vitro docking studies

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Title Synthesis and characterisation of novel tetradentate Schiff base complexes: Biological evaluation exploring anticancer activity towards MCF 7 cell breast cancer lines with in vitro docking studies
 
Creator Manimalathi, S
Madheswari, D
 
Subject Tetradentate Schiff base
New transition metal complex
Biological evaluation
Docking with DNA
Microbial studies and cytotoxicity
 
Description 965-975
A method to synthesize novel tetradentate ligand and a new series of metal complexes comprising Co (II), Fe (II), Cu (II) and
Zn (II) (1-4) using 3,5-dichlorosalicylaldehyde and trans 1,2-diaminocyclohexane is described. The structural features and mode of
bonding exhibited by Schiff base have been characterized by spectral methods like UV-visible, FT-IR and ESI-MS. Schiff base
ligand and (1-4) complexes have displayed superior antibacterial towards both Gram positive and Gram negative bacteria. The
antioxidant studies have revealed significant free radical scavenging activity towards the free radical DPPH. Theoretical molecular
docking studies are performed to elucidate the interactions of synthesized compounds with biomolecules. A model illustrating
specific DNA-binding of synthesized compounds and groove binding mode of DNA interaction is evolved. Cu(II) complex (3)
with more pronounced biological activity (antibacterial and antioxidant) has been subjected to cytotoxicity studies against MCF-7
breast cancer cell lines through MMT assay. Cu (II) complex have exhibited stronger anti-cancer activity in comparision to ligand
in that way the synergistic effects of signifying Cu Schiff base complexes illustrate the higher inhibiting efficiency of 77.2% at
320 μg/mL. The proposed study, therefore discloses potentiality of the synthesized new Schiff base derived complexes as a prodrug
for cancer treatment.
 
Date 2022-09-19T10:14:18Z
2022-09-19T10:14:18Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60508
https://doi.org/10.56042/ijc.v61i9.66350
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]