Record Details

DMAP-catalysed synthesis, antibacterial activity evaluation, cytotoxicity and docking studies of some heterocyclic molecules bearing sulfonamide moiety

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title DMAP-catalysed synthesis, antibacterial activity evaluation, cytotoxicity and docking studies of some heterocyclic molecules bearing sulfonamide moiety
 
Creator Naaz, Farha
Srivastava, Ritika
Yadav, Madhu
Singh, Vishal K
Mishra, Richa
Chaurasia, Himani
Singh, Ramendra K
 
Subject DMAP
sulfonamides
antibacterial activity
molecular docking
peptide deformylase inhibitor
 
Description 951-960
DMAP has been shown to be a highly efficient nucleophilic catalyst when compared to triethylamine and pyridine using
acetonitrile as solvent for the synthesis of a series of novel N- heterocyclic sulfonamide derivatives. The influence of the
reaction parameters, like choice of solvent, catalyst, amount of catalyst and reaction time on product yield has been studied.
Antibacterial screening involving a range of sulfonamide analogues as new peptide deformylase (PDF) inhibitors have been
focused. The molecules show significant antibacterial activity (MIC value 6.2 − 3.1 μg/mL) against B. subtilis, S. pyrogenes,
P. vulgaris and P. mirabilis. Potential in silico docking studies have been in conjugation with in vitro antibacterial results.
Molecular docking of all compounds with PDF enzyme (PDB code: 1G2A) explain how certain moieties play significant
roles in increasing the binding interactions and stabilizing the protein-ligand complexes. The compounds also confirm low
extent of cytotoxicity when tested on HEL and HeLa cell lines.
 
Date 2022-09-19T10:22:46Z
2022-09-19T10:22:46Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60510
https://doi.org/10.56042/ijc.v61i9.66345
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]