A convenient and eco-friendly one-pot synthesis of 3-triazolyl-2-iminochromenes and investigation of their antioxidant properties
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Title |
A convenient and eco-friendly one-pot synthesis of 3-triazolyl-2-iminochromenes and investigation of their antioxidant properties
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Creator |
Basha, Khadhar Navaz Umar
Gnanamani, Shanthi Shanmugam, Prakash Venugopal, Sujatha |
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Subject |
Multicomponent reaction
2-azido acetonitrile salicylaldehyde phenylacetylene CuI/K2CO3 chromenes |
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Description |
943-950
A simple, green and efficient procedure for the synthesis of highly functionalized 3-triazolyl-2-iminochromenes by using a one-pot three component reaction of 2-azido acetonitrile, phenylacetylene and salicylaldehyde in water using CuI/K2CO3 is described. The present protocol offers advantages like high atom economy, simple methodology, shorter reaction time, easy product isolation, no chromatographic purification and avoidance of environmentally hazardous solvents. Compounds 4a-d, 4g-h and 6a-b have been investigated for antioxidant activity. Compound 4c is found to be the most active among the series showing high reducing power and free radical scavenging activity. |
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Date |
2022-09-20T10:09:10Z
2022-09-20T10:09:10Z 2022-09 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60513 https://doi.org/10.56042/ijc.v61i9.66344 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.61(09) [Sep 2022]
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