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A convenient and eco-friendly one-pot synthesis of 3-triazolyl-2-iminochromenes and investigation of their antioxidant properties

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Title A convenient and eco-friendly one-pot synthesis of 3-triazolyl-2-iminochromenes and investigation of their antioxidant properties
 
Creator Basha, Khadhar Navaz Umar
Gnanamani, Shanthi
Shanmugam, Prakash
Venugopal, Sujatha
 
Subject Multicomponent reaction
2-azido acetonitrile
salicylaldehyde
phenylacetylene
CuI/K2CO3
chromenes
 
Description 943-950
A simple, green and efficient procedure for the synthesis of highly functionalized 3-triazolyl-2-iminochromenes by
using a one-pot three component reaction of 2-azido acetonitrile, phenylacetylene and salicylaldehyde in water using
CuI/K2CO3 is described. The present protocol offers advantages like high atom economy, simple methodology, shorter
reaction time, easy product isolation, no chromatographic purification and avoidance of environmentally hazardous solvents.
Compounds 4a-d, 4g-h and 6a-b have been investigated for antioxidant activity. Compound 4c is found to be the most
active among the series showing high reducing power and free radical scavenging activity.
 
Date 2022-09-20T10:09:10Z
2022-09-20T10:09:10Z
2022-09
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60513
https://doi.org/10.56042/ijc.v61i9.66344
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(09) [Sep 2022]