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DMAP-catalysed synthesis, antibacterial activity evaluation, cytotoxicity and docking studies of some heterocyclic molecules bearing sulfonamide moiety

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Title Statement DMAP-catalysed synthesis, antibacterial activity evaluation, cytotoxicity and docking studies of some heterocyclic molecules bearing sulfonamide moiety
 
Added Entry - Uncontrolled Name Naaz, Farha ; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Srivastava, Ritika ; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Yadav, Madhu ; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Singh, Vishal K; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Mishra, Richa ; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Chaurasia, Himani ; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
Singh, Ramendra K; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Prayagraj 211 002, India
 
Uncontrolled Index Term DMAP, sulfonamides, antibacterial activity, molecular docking, peptide deformylase inhibitor
 
Summary, etc. <p style="text-align: justify;">DMAP has been shown to be a highly efficient nucleophilic catalyst when compared to triethylamine and pyridine using acetonitrile as solvent for the synthesis of a series of novel <em>N</em>- heterocyclic sulfonamide derivatives. The influence of the reaction parameters, like choice of solvent, catalyst, amount of catalyst and reaction time on product yield has been studied. Antibacterial screening involving a range of sulfonamide analogues as new peptide deformylase (PDF) inhibitors have been focused. The molecules show significant antibacterial activity (MIC value 6.2 − 3.1 µg/mL) against <em>B. subtilis</em>, <em>S. pyrogenes</em>, <em>P. vulgaris</em> and <em>P. mirabilis</em>. Potential <em>in silico</em> docking studies have been in conjugation with <em>in vitro</em> antibacterial results. Molecular docking of all compounds with PDF enzyme (PDB code: 1G2A) explain how certain moieties play significant roles in increasing the binding interactions and stabilizing the protein-ligand complexes. The compounds also have confirmed low extent of cytotoxicity when tested on HEL and HeLa cell lines.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-09-20 12:49:50
 
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http://op.niscair.res.in/index.php/IJC/article/view/66345
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 9 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en