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<strong>Novel pyrazole-pyridine containing 4-thiazolidinone hybrids: Design, synthesis and antimicrobial activity</strong>

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Title Statement <strong>Novel pyrazole-pyridine containing 4-thiazolidinone hybrids: Design, synthesis and antimicrobial activity</strong>
 
Added Entry - Uncontrolled Name Desai, Nisheeth C; Maharaja Krishnakumarsinhji Bhavnagar University
Jadeja, Dharmpalsinh J; Maharaja Krishnakumarsinhji Bhavnagar University
 
Uncontrolled Index Term Pyrazole, pyridine, 4-thiazolidinone, antibacterial, antifungal
 
Summary, etc. <p>The emergence of antimicrobial resistance (AMR) to currently available antimicrobial agents is a major source of concern for scientists. Antibiotic treatment against numerous bacteria and fungus is no longer effective due to antimicrobial resistance, as bacteria and fungi have developed to fight antibiotics and proven them ineffective or less efficient. Novel antimicrobial drugs that are effective against resistant strains are desperately needed. In continuation to this, we have designed and synthesized 4-thiazolidinone clubbed pyridine-pyrazole analogues <strong>(5a-5o)</strong> for the evaluation of antimicrobial activity. The structures of the newly prepared compounds were analyzed and confirmed by using IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectroscopy. Synthesized compounds have tested against various bacterial and fungal strains. Among the tested compounds, compounds <strong>5b, 5g</strong> and <strong>5m</strong> (MIC value of 62.5 μg/mL) have exhibited potency against <em>E. coli</em> gram-negative strain while compounds <strong>5a, 5c, 5g, 5i</strong> and <strong>5l</strong> (MIC = 250 μg/mL) were active against <em>C. albicans</em> fungal strain.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-09-20 12:49:50
 
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http://op.niscair.res.in/index.php/IJC/article/view/59848
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 9 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJC/article/download/59848/465595808
http://op.niscair.res.in/index.php/IJC/article/download/59848/0
http://op.niscair.res.in/index.php/IJC/article/download/59848/465595811
http://op.niscair.res.in/index.php/IJC/article/download/59848/465595813