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Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

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Title Statement Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents
 
Added Entry - Uncontrolled Name Chavan, Harshal ; Sir Dr. M S Gosavi College of Pharmaceutical Education and Research, Nashik, 422 005 India
Shirodkar, Prutha ; S M B T College of Pharmacy, Nashik, Maharastra-422 403, India
Mogal, Rajendra ; Sandip Foundation’s, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharastra-422 213, India
Amrutkar, Sunil ; Sir Dr. M S Gosavi College of Pharmaceutical Education and Research, Nashik, 422 005 India
 
Uncontrolled Index Term Thiosemicarbazide, 1,2,4-triazole, antimicrobial activity, antifungal activity, anthelmintic activity
 
Summary, etc. <p class="Abstract" style="text-align: justify;"><span lang="EN-GB">Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL.</span></p><br />
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-09-20 12:49:50
 
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http://op.niscair.res.in/index.php/IJC/article/view/66354
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 9 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en