Record Details

Effect of herbicide based formulations on structure and function of testis in rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Effect of herbicide based formulations on structure and function of testis in rats
 
Creator Phusate, Vaishali T.
 
Subject Follicle-stimulating hormone (FSH)
Gramoxone®
Luteinizing hormone (LH)
Post pubertal stage
Roundup®
Testosterone
Weed management
 
Description 805-809
Herbicides are known to add toxicity to the soil as their side
effect. Farmers use either Paraquat based (PBF) or Glyphosate
based (GBF) herbicide formulations for instant management of
weeds. Here, we investigated the effect of PBF Gramoxone® and
GBF Roundup® on the structure and function of the testis of the
male Wistar rats at the pubertal or post pubertal stage. Male rats
were gavaged with Gramoxone® (5 mg/kg body wt.) or
Roundup® (250 mg/kg body wt.). The treatment period of
25 days starts on a postnatal day (PND) 28 to 53 (from prepubertal
to the pubertal stage) or 60 days from PND 28 to 88
(from prepubertal to the post pubertal stage). Age-matched control
animals received distilled water. The structure of the testes was
evaluated by observing changes in its histology and the function
of the testes was assessed by estimating serum follicle-stimulating
hormone (FSH), luteinizing hormone (LH) and testosterone
levels. No significant effect was observed in the structure and
function of the testes of the pubertal stage rats on exposure to both
herbicide formulations. However, shrunken and distorted
seminiferous tubules with oligozoospermia in testes, a nonsignificant
decrease in FSH and LH, and a significant reduction in
testosterone levels were noted in the post pubertal stage rats. The
results indicated that changes in the testes of post pubertal groups
are due to a longer duration of exposure to the Gramoxone® or
Roundup® than in pubertal groups, and also the effect of these
two formulations was more on the testis structure and function
than on the pituitary-testis axis.
 
Date 2022-09-29T08:48:59Z
2022-09-29T08:48:59Z
2022-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60569
https://doi.org//10.56042/ijeb.v60i10.34811
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(10) [Oct 2022]