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Antiproliferative and cytotoxic activities of Mentha x piperita L. essential oil in non-small cell lung cancer cells

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Title Antiproliferative and cytotoxic activities of Mentha x piperita L. essential oil in non-small cell lung cancer cells
 
Creator Yücel, Dilge
Sezer, Canan Vejselova
Yücel, Ersin
Kutlu, Hatice Mehtap
 
Subject Anticancer activity
Apoptosis
Growth supression
Peppermint
 
Description 753-758
Among 33 types of listed cancers worldwide, lung cancer with 2.2 million cases (12.2% of total cancer cases) ranks second next only to breast cancer. Globally, Turkey, with overall rate of 40.0 (41,264 cases), ranks 5th among the top 10 countries in lung cancer. Currently used therapeutic agents and approaches have considerable side effects, and hence, there is a need for alternative agents for effective management of lung cancer. In this study, we explored the in vitro cytotoxic, antiproliferative and proapoptotic activities of Mentha x piperita L. (peppermint) essential oil in human non-small cell lung cancer (A549) cells. Cell viability was determined by MTT assay, morphological changes were determined by confocal microscopy and apoptosis promoting action was determined by flow cytometry technique. Peppermint essential oil found to effectively decrease the viability of non-small cell lung cancer cells and IC50 value was detected at low concentrations (2.12%) for 24 h. In addition, peppermint essential oil was found to alter the morphology of A549 cells, leading to changes that could describe programmed cell death. Apoptosis was the triggered cell death by Mentha x piperita essential oil. Results reveal that Mentha x piperita essential oil has antiproliferative and anticarcinogenic properties which could be attributed to the bioactive phytochemical contents and has the potential to be used as an anticancer agent and chemotherapeutic drug.
 
Date 2022-09-29T09:05:36Z
2022-09-29T09:05:36Z
2022-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60575
https://doi.org/10.56042/ijeb.v60i10.47280
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(10) [Oct 2022]