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LC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent.

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Title LC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent.
 
Creator Hazman, Omer
Aksoy, Laçine
Büyükben, Ahmet
Kara, Recep
Kargıoglu, Mustafa
Cigerci, İbrahim Hakkı
Yılmaz, Mustafa Abdullah
 
Subject Anticancer
Antimicrobial
Antioxidant
Cytotoxic
Folk medicine
ICP-OES
Phenolic content
Sheepskin grass
Traditional medicine
 
Description 743-752
Plants belonging to the genus Hypericum L. are widely used in traditional folk medicine due to their hypericin and
pseudohypericin contents. In this study, we investigated the biological activity, phenolic and elemental content of methanol
and acetone extracts of sheepskin grass, Hypericum heterophyllum Vent. a species that that lacks both hypericin and
pseudohypericin. The total antioxidant status of the extracts was determined by commercial kits. Antibacterial effect of
extracts was investigated on seven bacterial strains. Cytotoxic effects of the extracts on lung cancer cell lines were
determined by MTT (3-4,5-dimethyl-thiazolyl-2,5-diphenyltetrazolium bromide) method. Phenolic content was determined
by LC-ESI-MS/MS. Elements in the plant were determined by ICP-OES. The total phenolic content and antioxidant status
of the species’ methanol extract were found to be higher than the acetone extract. Both of the extracts at a concentration of
20% have an antibacterial effect, especially the antibacterial effect of acetone extract. It was determined that acetone extract
has an anticarcinogenic impact depending on the dose. Chlorogenic acid, miquelianin and isoquercitrin are the most
abundant flavonoids in methanol and acetone extract. The plant contains Ca, K, and Mg elements in high concentrations.
The phenolic substances and elements in H. heterophyllum, widely used in our country, have been presented for the first
time in the literature. Besides, it can be said that the plant has antioxidant, anticarcinogen, and antimicrobial activities due to
the crucial flavonoids and elements it contains.
 
Date 2022-09-29T09:09:29Z
2022-09-29T09:09:29Z
2022-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60576
https://doi.org/10.56042/ijeb.v60i10.55070
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(10) [Oct 2022]