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Effect of herbicide based formulations on structure and function of testis in rats

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Title Statement Effect of herbicide based formulations on structure and function of testis in rats
 
Added Entry - Uncontrolled Name Phusate, Vaishali Tulsiram; Ramnarain Ruia Autonomous College
University Grants Commission, New Delhi
 
Uncontrolled Index Term Follicle-stimulating hormone (FSH); Gramoxone®; Luteinizing hormone (LH); Post pubertal stage; Roundup®; Testosterone; Weed management
 
Summary, etc. <p style="text-align: justify;"><span lang="EN-GB">For instant weed management, widely used herbicide formulations (HFs) are Paraquat based formulation (PBF) or Glyphosate based formulation (GBF). Here, we investigated the effect of PBF Gramoxone® and GBF Roundup® on the structure and function of the testis of the male Wistar rats at the pubertal or post pubertal stage. Male rats were gavaged with Gramoxone® (5 mg/kg body wt.) or Roundup® (250 mg/kg body wt.). The treatment period of 25 days starts on a postnatal day (PND) 28 to 53 (from pre-pubertal to the pubertal stage) or 60 days from PND 28 to 88 (from prepubertal to the post pubertal stage). Age-matched control animals received distilled water. The structure of the testes was evaluated by observing changes in its histology and the function of the testes was assessed by estimating serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone levels. No significant effect was observed in the structure and function of the testes of the pubertal stage rats on exposure to both herbicide formulations. However, shrunken and distorted </span><span lang="EN-US">seminiferous tubules with </span><span lang="EN-GB">oligozoospermia</span><span lang="EN-GB"> in testes, a non-significant decrease in FSH and LH, and a significant reduction in testosterone levels were noted in the post pubertal stage rats. The results indicated that changes in the testes of post pubertal groups are due to a longer duration of exposure to the </span><span lang="EN-US">Gramoxone</span><span lang="EN-GB">® or Roundup®</span><span lang="EN-US"> than in </span><span lang="EN-GB">pubertal groups, </span><span lang="EN-US">and also the effect of these two formulations </span><span lang="EN-GB">was more on the testis structure and function than on the pituitary-testis axis</span></p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-09-29 11:43:29
 
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http://op.niscair.res.in/index.php/IJEB/article/view/34811
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 10 (2022): IJEB [OCTOBER 2022]
 
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