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Antioxidative potential of propolis on Staphylococcus aureus infected BALB/c mice: A biochemical study

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Title Antioxidative potential of propolis on Staphylococcus aureus infected BALB/c mice: A biochemical study
 
Creator Rana, Anita
Kumar, Neelima R
 
Subject Ampicillin
Amoxicillin
Bee products
Kidney
Liver
Oxidative stress
Spleen
 
Description 1006-1015
Drug resistance, according to World Health Organization, is one of the most serious threats to public health. This makes
antibiotics ineffective and reduces their therapeutic potential. One of the most prevalent multidrug-resistant bacteria is
Staphylococcus aureus which is considered to be the most common pathogen and mortality factor in both hospital and nonhospital
environments worldwide. Due to an unprecedented increase in reports of drug resistance in pathogens, and also due
to adverse and severe side effects of drugs, there is an urgent need to redirect scientific efforts towards search for antioxidative
natural substances and other alternative sources having therapeutic potential against microbes. Natural products
such as propolis seem to exhibit most promising therapeutic potential against microorganisms. Thus, present study is
focused on antioxidative potential of propolis in combination with standard antibiotics ampicillin and amoxicillin against
S. aureus infected BALB/c mice. For this, mice were divided into seven groups, they were decapitated after suitable
experimental periods, then their liver, kidney and spleen were excised from control and experimental groups, which were
homogenized and then used for different biochemical estimations following the standard protocols. Results showed that
S. aureus caused severe biochemical alterations by 5th day of infection that is, lipid peroxidation increased significantly
(P
 
Date 2022-10-06T09:16:56Z
2022-10-06T09:16:56Z
2022-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60635
https://doi.org/10.56042/ijbb.v59i10.58820
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(10) [Oct 2022]