Record Details

Exposure to an enriched environment promotes dendritic remodelling in hippocampal neurons affected by endogenous depression

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Exposure to an enriched environment promotes dendritic remodelling in hippocampal neurons affected by endogenous depression
 
Creator V, Bhagya
VK, Sindhu
K, Mahati
BS, Shankaranarayana Rao
 
Subject Environamental enrichment,
Memory
Neuronal morphology
Psychiatric disorders
 
Description 998-1005
Neuronal plasticity is enhanced in an enriched environment (EE) with more sensory and social interaction. In an animal
model of endogenous depression, we have previously shown that EE has positive effects on spatial memory and hippocampus
synaptic plasticity. However, nothing is known about how EE influences dendritic remodelling in hippocampal neurons affected
by endogenous depression. In depressed rats, the impact of EE on hippocampus neuronal morphology was examined. Neonatal
clomipramine exposure from postnatal days (PND) 8-21 days induced endogenous depression. The depressed-like rats were
exposed to an enriched environment for two weeks in adulthood. Brains were then collected, stained with a modified Golgi-cox
technique and, the hippocampal CA1 dendritic arborisation was evaluated using the Neurolucida software. Depression resulted
in the atrophy of CA1 hippocampal neurons. The number of branching points and the overall number of dendritic intersections
were reduced in depressed rats,. Exposure to an enriched environment significantly increased dendritic branching and the total
number of dendritic intersections in hippocampal CA1 pyramidal neurons. The hippocampal pyramidal neuronal morphology of
depressed rats improved after exposure to environmental enrichment. Neuronal plasticity and the development of novel
therapeutic strategy will be improved by a greater understanding of how the environment affects neuronal morphology in
depressed states.
 
Date 2022-10-06T09:21:53Z
2022-10-06T09:21:53Z
2022-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60636
https://doi.org/10.56042/ijbb.v59i10.57620
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(10) [Oct 2022]