ICAR Research Data Repository for Knowledge Management
Assessment of cranberry bush on MCF-7 human breast cancer cells
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
Assessment of cranberry bush on MCF-7 human breast cancer cells
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| Creator |
Kaan, Dilek
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| Subject |
Alternative medicine
Apoptosis Genotoxicity effects Metabolic protein level |
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| Description |
985-997
This research aimed to study the therapeutic potential of Viburnum opulus L. (VO) powder extracts on human breast cancer and normal breast epithelial cell lines. The half-maximum inhibitory concentration IC50 value was 51.32 μg/mL for 24 h using an MTT assay. The total apoptotic induction was found to be 40.50% for MCF-7 cells exposed to 100 μg/mL VO powder extract for 48 h. The genotoxic effect in MCF-7 cells was statistically significantly increased in a dose-dependent manner after exposure to VO powder extracts. P1 class glutathione-S-transferase (GSTP1) expression level was noticed protective feature in drug resistance metabolism. GSTP1 activities were found statistically significant differences between all of the groups (**P |
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| Date |
2022-10-06T09:25:45Z
2022-10-06T09:25:45Z 2022-10 |
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| Type |
Article
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| Identifier |
0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60637 https://doi.org/10.56042/ijbb.v59i10.65517 |
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| Language |
en
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| Publisher |
NIScPR-CSIR,India
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| Source |
IJBB Vol.59(10) [Oct 2022]
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