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<p style="text-align: justify;">Development of cucurbocitrin based nutraceutical formulation: A potential adjuvant herbal therapy in the management of hypertension</p>

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Title Statement <p style="text-align: justify;">Development of cucurbocitrin based nutraceutical formulation: A potential adjuvant herbal therapy in the management of hypertension</p>
 
Added Entry - Uncontrolled Name Bhardwaj, Snigdha ; I.T.S College of Pharmacy, Murad Nagar, Ghaziabad 201206, Uttar Pradesh, India
Bhatia, Sonam ; Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, SHUATS, Naini, Prayagraj 211007, Uttar Pradesh, India
Gupta, Pushpraj S.; Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, SHUATS, Naini, Prayagraj 211007, Uttar Pradesh, India
Singh, Shaminder ; Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurugram Expressway, Faridabad 121 001, Haryana, India
Badal, Sachendra ; Department of Pediatrics, Armed Forces Medical College (AFMC), Wanowrie, Pune 411040, Maharashtra, India
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Uncontrolled Index Term Plant based herbal formulations
Adjuvant therapy; Citrullus lanatus (watermelon); Cucurbocitrin; Hypertension; Nutraceutical; Toxicity.
 
Summary, etc. <p style="text-align: justify;">Nearly half of the hypertensive patients fail to manage their blood pressure despite pharmacological interventions, which reflects the dire need for adjuvant anti-hypertensive therapies. Nutraceutical formulations are attractive in this regard owing to their efficacy, ease of availability, and moderate pricing. The current investigation involves the formulation of cucurbocitrin nutraceutical tablets by direct compression method and evaluated for its anti-hypertensive effect in the management of hypertension. Cucurbocitrin is a natural compound prepared from <em>Citrullus lanatus</em> seeds belonging to the family Cucurbitaceae. The powder blend was examined for pre-compression studies such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, etc. Based on acute-oral toxicity results, two tablet formulations were prepared using a different dose of cucurbocitrin and evaluated for post-compression parameters such as friability, hardness, weight variation, disintegration time, and <em>in vitro</em> drug release studies. <em>In vivo</em> studies were also performed for both formulations using a 10% Glucose solution-induced hypertension model in albino rats to observe its anti-hypertensive activity. The study indicated that nutraceutical formulation was found to be effective in reducing hypertension in an animal model.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-09-06 11:30:19
 
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Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 3 (2022): September 2022 (Ahead of Print)
 
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