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Antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of Gynura nepalensis DC. and isolation of its steroid constituents

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Title Antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of Gynura nepalensis DC. and isolation of its steroid constituents
 
Creator Bari, Md. Sazzadul
Das, Amit Chandra
Bhuiyan, Md. Mohi Uddin
Khatun, Sonia
Mitu, Anjumanara
Khandokar, Labony
 
Subject Anti-inflammatory
Antioxidant
Cytotoxic
Gynura nepalensis
Sterols
Thrombolytic
 
Description 329-338
The study was aimed at phytochemical profiling of Gynura nepalensis DC. as well as assessment of possible antioxidant,
anti-inflammatory, thrombolytic, and cytotoxic activities of its fractions named hexane (HSF), dichloromethane (DCMSF),
ethyl acetate (EASF) and aqueous (AQSF) soluble fractions through in vitro assays. Chromatographic fractionation and
purification followed by 1H NMR spectral analysis afforded two sterols named β-sitosterol and stigmasterol, which appears
to be a first-time reporting from the species. In the free radical scavenging assay, both DCMSF and EASF exhibited
prominent antioxidant activities which was further reinforced by their comparatively greater phenolic content. In membrane
stabilizing test, prominent inhibitions of hemolysis as exerted by EASF, AQSF, and DCMSF, were evident of their
significant anti-inflammatory activities, compared to aspirin. With respect to streptokinase, HSF and DCMSF demonstrated
moderate thrombolytic properties, whereas in the cytotoxicity study, only HSF illustrated prominent cytotoxic properties. In
conclusion, the results are suggestive of the presence of bioactive molecules within the fractions capable of exerting potent
pharmacological activities.
 
Date 2022-10-18T06:28:35Z
2022-10-18T06:28:35Z
2022-10
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60682
https://doi.org/10.56042/ijnpr.v13i3.37833
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(3) [September 2022]