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Development of cucurbocitrin based nutraceutical formulation: A potential adjuvant herbal therapy in the management of hypertension

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Title Development of cucurbocitrin based nutraceutical formulation: A potential adjuvant herbal therapy in the management of hypertension
 
Creator Bhardwaj, Snigdha
Bhatia, Sonam
Gupta, Pushpraj S
Singh, Shaminder
Badal, Sachendra
 
Subject Adjuvant therapy
Citrullus lanatus (watermelon)
Cucurbocitrin
Hypertension
Nutraceutical
Toxicity
 
Description 318-328
Nearly half of the hypertensive patients fail to manage their blood pressure despite pharmacological interventions, which
reflects the dire need for adjuvant anti-hypertensive therapies. Nutraceutical formulations are attractive in this regard owing to
their efficacy, ease of availability, and moderate pricing. The current investigation involves the formulation of cucurbocitrin
nutraceutical tablets by direct compression method and evaluated for its anti-hypertensive effect in the management of
hypertension. Cucurbocitrin is a natural compound prepared from Citrullus lanatus seeds belonging to the family
Cucurbitaceae. The powder blend was examined for pre-compression studies such as angle of repose, bulk density, tapped
density, Carr’s index, Hausner's ratio, etc. Based on acute-oral toxicity results, two tablet formulations were prepared using a
different dose of cucurbocitrin and evaluated for post-compression parameters such as friability, hardness, weight variation,
disintegration time, and in vitro drug release studies. In vivo studies were also performed for both formulations using a 10%
Glucose solution-induced hypertension model in albino rats to observe its anti-hypertensive activity. The study indicated that
nutraceutical formulation was found to be effective in reducing hypertension in an animal model.
 
Date 2022-10-18T06:32:50Z
2022-10-18T06:32:50Z
2022-10
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60683
https://doi.org/10.56042/ijnpr.v13i3.54840
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(3) [September 2022]