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Evaluation of in vivo antidiabetic activity of Notonia grandiflora Wall.

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Title Evaluation of in vivo antidiabetic activity of Notonia grandiflora Wall.
 
Creator Paul, Meera
R Sanilkumar2
C, Sabu M
 
Subject Antidiabetic activity
Ethyl acetate extract
In vivo
Notonia grandiflora
Streptozotocin
 
Description 310-317
The aim of this study was to determine the in vivo hypoglycaemic activity of ethyl acetate extract of Notonia grandiflora (EANG) in albino wistar rats. EANG was orally administrated to STZ (40 mg/kg, i.p, b.w) induced diabetic rats at the doses of 100 and 200 mg/kg b.w for 21 days. The effect of EANG on blood glucose, body weight, plasma insulin, urea, uric acid, creatinine, Hb, HbA1C, liver glycogen content, bilirubin level, liver enzymes (Serum glutamate pyruvate transaminases, serum glutamate oxaloacetate transaminases, alkaline phosphatase) were measured in the diabetic rats. Treatment of EANG significantly lowered the levels of blood glucose and glycosylated haemoglobin. It also restored body weight, liver glycogen content, and serum insulin level in diabetic rats in a dose-dependent manner. A significant reduction in the activity of liver function enzymes associated with diabetes and serum levels of renal parameters after treatment with EANG was observed, signifying the protective effects of EANG in diabetes-associated complications. Hence, it could be used as a safer complementary drug in the management of diabetes and associated complications.
 
Date 2022-10-18T06:34:56Z
2022-10-18T06:34:56Z
2022-10
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60684
https://doi.org/10.56042/ijnpr.v13i3.52630
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(3) [September 2022]