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Ethno medicinal plants with anticonvulsant activity through GABAergic mechanism- A review

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Title Ethno medicinal plants with anticonvulsant activity through GABAergic mechanism- A review
 
Creator Jangra, Sachin
Manjusha
Budhwar, Vikas
 
Subject Anticonvulsant
Epilepsy
GABA
Herbal medicine
 
Description 274-286
Humanity has used immemorial plants for their relieving and healing powers from era and we still depend on their
healing properties. Plants with number of active constituents have a direct therapeutic impact on various body organs. Brain
is one of major organ linked to various disorders, one of them is epilepsy. Owing to undesirable side effects, high expense
and reduced effectiveness of conventional drugs, traditional plants are deemed appropriate for the treatment of epilepsy. The
potential of natural products for the treatment of epilepsy can be an excellent alternative for the development of safe and
effective anti-epileptic drugs. The present bibliographic review presents the data upto 2021. Plants were screened for citing
the research work done for epilepsy, efficacy of plants along with their mechanism of action, plant profile, part used, dose,
extract used, toxicity study and model used. Also isolated compounds have been compiled along with their structure. A total
of 120 review and research articles of plants which revealed their effective therapeutic effects on epilepsy through
GABAergic transmission belonging to families lamiaceae(11), fabaceae(5), zingiberaceae(3), moraceae(3), verbenaceae(3),
and apiaceae(2). The data discussed might be useful in formulating new chemical entity for the treatment of epilepsy. The
documentation of isolated compounds may provide new drug molecules for market with lesser cost and more efficacy.
 
Date 2022-10-18T06:41:29Z
2022-10-18T06:41:29Z
2022-10
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60687
https://doi.org/10.56042/ijnpr.v13i3.35856
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(3) [September 2022]