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<p style="text-align: justify;">Design of an efficient three component one-pot synthesis of -1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1<em>H</em>-indol-3-yl)-2-thioxopyrimidine-5-carbonitrile as antimicrobial and antitubercular agent</p>

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Title Statement <p style="text-align: justify;">Design of an efficient three component one-pot synthesis of -1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1<em>H</em>-indol-3-yl)-2-thioxopyrimidine-5-carbonitrile as antimicrobial and antitubercular agent</p>
 
Added Entry - Uncontrolled Name Walmik, Prabhaker ; Department of Post-Graduate Studies and Research in Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga 585 106, India
 
Uncontrolled Index Term Indole, pyrazole, pyrimidin-2-one, antimicrobial activity, antitubercular activity
 
Summary, etc. <p style="text-align: justify;">In the present study, a novel, rapid, improved and eco-friendly synthesis of indolyl-pyrazolo-pyrimidine derivatives <strong>4a-c</strong> by using conventional method <em>via</em> one-pot multi-component reaction has been described. The structures of all these unknown compounds have been confirmed with the help of physical and spectroscopic techniques like IR, <sup>1</sup>H and <sup>13</sup>C NMR and mass spectrometry and these newly synthesized compounds have been evaluated for <em>in vitro</em> antimicrobial and antitubercular and antioxidant activities. The results reveal that compound<strong> 4a</strong> exhibits promising antimicrobial, antitubercular and antioxidant properties when compared to the standard drugs.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-10-21 16:51:33
 
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http://op.niscair.res.in/index.php/IJC/article/view/67200
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 10 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en