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<strong>Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo[1,2-<em>b</em>]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones</strong>

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Title Statement <strong>Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo[1,2-<em>b</em>]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones</strong>
 
Added Entry - Uncontrolled Name MARRI, SRINIVAS ; Siddhartha Degree & P.G. College, (Affiliated to Kakatiya University)
 
Uncontrolled Index Term 6-Methyl-3-arylimidazolo[1,2-b]isoxazoles, 1,3,5-triazinane-2-thiones, trimolecular condensation, antibacterial activity, antifungal activity
 
Summary, etc. Synthesis of novel 5-methyl-1-(4-(6-methylimidazo[1,2-<em>b</em>]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones <strong>(6)</strong> has been achieved by the reaction of 3-amino-5-methylisoxazole <strong>1</strong> with <em>p</em>-nitro phenacyl bromide, followed by reduction of  <strong>3</strong> with stannous chloride. Compounds <strong>4</strong> on treatment with different aryl isothiocyanates in refluxing benzene, followed by trimolecular condensation with 30% HCHO and methyl amine in ethanol afforded the title compounds <strong>(6).</strong> The newly synthesized compounds (<strong>6)</strong> have been evaluated for their <em>in vitro</em> antimicrobial activity. Compounds<strong> 6</strong> exhibited potent antimicrobial activity compared to that of standard drugs.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-10-21 16:51:33
 
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http://op.niscair.res.in/index.php/IJC/article/view/62377
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 10 (2022): Indian Journal of Chemistry-(IJC)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJC/article/download/62377/465606277
http://op.niscair.res.in/index.php/IJC/article/download/62377/465606278