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<p class="Title1">Synthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole</p>

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Title Statement <p class="Title1">Synthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole</p>
 
Added Entry - Uncontrolled Name Choudhary, Sunil Kumar; Department of Biotechnology and Allied Sciences, Faculty of Education and Methodology, Jayoti Vidyapeeth Women’s University. Jaipur 303 122, India
Trivedi, Monika ; Department of Biotechnology and Allied Sciences, Faculty of Education and Methodology, Jayoti Vidyapeeth Women’s University. Jaipur 303 122, India
Sogani, Nidhi ; Department of Chemistry, The IIS University, Jaipur 302 020, India
 
Uncontrolled Index Term Carbamates, 4-amino-1,2,4-triazole, bicarbamates, 3-(methylthio)-4-amino-1,2,4-triazole, solvent effect, base effectSynthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole
 
Summary, etc. <p class="Adress" style="text-align: justify;">Carbamate derivatives are proved to be an essential class of molecules because of their application as drugs and prodrugs. Their several derivatives also have been used to craft the drug-target interfaces by incorporating the carbamate moiety. Due to the huge demand in pharma-industries these have been extensively explored and synthesized. The synthesis and characterization of carbamate derivatives from 4-amino-1,2,4-triazoles and 3-(methylthio)-4-amino-1,2,4-triazoles are described. Carbamate derivatives of 4-amino-1,2,4-triazoles with phenyl chloroformate in CH<sub>3</sub>CN using K<sub>2</sub>CO<sub>3</sub> at <em>ca</em>. ~80°C have been synthesized with good to excellent yield (~81 to 97%). The methodology has been subsequently extended for synthesis of carbamate derivatives of 3-(methylthio)-4-amino-1,2,4-triazoles in which bicarbamate derivatives are formed as major products (~39 to 47%) along with mono carbamate derivatives as minor products (~9 to 22%) in the presence of similar solvent and base. On investigating the effect of solvent and base, the reaction in CH<sub>3</sub>CN in presence of K<sub>2</sub>CO<sub>3</sub> shows the best results.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-10-21 16:51:33
 
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http://op.niscair.res.in/index.php/IJC/article/view/67203
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 10 (2022): Indian Journal of Chemistry-(IJC)
 
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