Design of an efficient three component one-pot synthesis of -1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1H-indol-3-yl)-2-thioxopyrimidine-5-carbonitrile as antimicrobial and antitubercular agent
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Title |
Design of an efficient three component one-pot synthesis of -1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1H-indol-3-yl)-2-thioxopyrimidine-5-carbonitrile as antimicrobial and antitubercular agent
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Creator |
Walmik, Prabhaker
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Subject |
Indole
Pyrazole Pyrimidin-2-one Antimicrobial activity Antitubercular activity |
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Description |
1134-1138
In the present study, a novel, rapid, improved and eco-friendly synthesis of indolyl-pyrazolo-pyrimidine derivatives 4a-c by using conventional method via one-pot multi-component reaction has been described. The structures of all these unknown compounds have been confirmed with the help of physical and spectroscopic techniques like IR, 1H and 13C NMR and mass spectrometry and these newly synthesized compounds have been evaluated for in vitro antimicrobial and antitubercular and antioxidant activities. The results reveal that compound 4a exhibits promising antimicrobial, antitubercular and antioxidant properties when compared to the standard drugs. |
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Date |
2022-10-21T04:34:38Z
2022-10-21T04:34:38Z 2022-10 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60715 https://doi.org/10.56042/ijc.v61i10.67200 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.61(10) [Oct 2022]
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