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An efficient sodium chloride-catalyzed synthesis of bis(indolyl) methanes in green solvent and their antibacterial evaluation

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Title An efficient sodium chloride-catalyzed synthesis of bis(indolyl) methanes in green solvent and their antibacterial evaluation
 
Creator Longkumer, Lensayula
Imchen, Putusenla
Zhimomi, Betokali K
Swu, Toka
Phucho, I Tovishe
 
Subject Bis(indolyl)methanes
Aldehydes
NaCl
Aqueous medium
Antibacterial
 
Description 1120-1123
A series of bis(indolyl)methanes derivatives have been synthesized using an efficient sodium chloride-catalyst in
aqueous medium. Herein, substituted aldehydes have been successfully condensed with indole in an aqueous medium.
Sodium chloride serves as an efficient and green catalyst as it is freely available and environmentally benign. Water used as
green solvent also has no negative impact on the environment. The experiment follows a simple reaction procedure and
completion of the reaction is achieved within 3-4 hours. The synthesized compounds have also been evaluated for their
in vitro antibacterial property using 4 strains of bacteria, namely Bacillus subtilis, Staphylococcus aureus, Escherichia coli
and Klebsiella pneumonia where Streptomycin is used as the reference standard.
 
Date 2022-10-21T04:42:02Z
2022-10-21T04:42:02Z
2022-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60717
https://doi.org/10.56042/ijc.v61i10.67208
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(10) [Oct 2022]