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Synthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole

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Title Synthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole
 
Creator Choudhary, Sunil Kumar
Trivedi, Monika
Sogani, Nidhi
 
Subject Carbamates
4-Amino-1,2,4-triazole
Bicarbamates
3-(Methylthio)-4-amino-1,2,4-triazole
Solvent effect
Base effect
 
Description 1113-1119
Carbamate derivatives are proved to be an essential class of molecules because of their application as drugs and prodrugs.
Their several derivatives also have been used to craft the drug-target interfaces by incorporating the carbamate moiety. Due to
the huge demand in pharma-industries these have been extensively explored and synthesized. The synthesis and characterization
of carbamate derivatives from 4-amino-1,2,4-triazoles and 3-(methylthio)-4-amino-1,2,4-triazoles are described. Carbamate
derivatives of 4-amino-1,2,4-triazoles with phenyl chloroformate in CH3CN using K2CO3 at ca. ~80°C have been synthesized
with good to excellent yield (~81 to 97%). The methodology has been subsequently extended for synthesis of carbamate
derivatives of 3-(methylthio)-4-amino-1,2,4-triazoles in which bicarbamate derivatives are formed as major products (~39 to
47%) along with mono carbamate derivatives as minor products (~9 to 22%) in the presence of similar solvent and base. On
investigating the effect of solvent and base, the reaction in CH3CN in presence of K2CO3 shows the best results.
 
Date 2022-10-21T04:45:49Z
2022-10-21T04:45:49Z
2022-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60718
https://doi.org/10.56042/ijc.v61i10.67203
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(10) [Oct 2022]