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One-pot Michael addition and cyclo-elimination cascade synthesis of thiazolo-[4,5-b]pyridin-6-carbonitrile scaffold

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Title One-pot Michael addition and cyclo-elimination cascade synthesis of thiazolo-[4,5-b]pyridin-6-carbonitrile scaffold
 
Creator Tiwari, Shailendra
Singh, Vishal Kumar
Rahmani, Shahla
Ahmad, Akeel
Begum, Kahkashan
 
Subject 3-Benzyl-4-thiazolidinon-2-thione
Carbonitrile
Antibacterial
antifungal activity
 
Description 1097-1102
A series of thiazolo [4,5-b]- pyridine-6-carbonitriles scaffold have been synthesized conveniently and smoothly in a
single step in good yields. These compounds have been screened for their antibacterial and antifungal activity against
different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal
concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3d,
3e, 3f, 4c, 4d, 4e and 4f have shown good antibacterial as well as antifungal activity.
 
Date 2022-10-21T04:51:56Z
2022-10-21T04:51:56Z
2022-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60720
https://doi.org/10.56042/ijc.v61i10.59435
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(10) [Oct 2022]