Record Details

Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Novel 1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs as efficient antimicrobial agents from N-arylsydnone as synthon
 
Creator Somagond, Shipa M
Kamble, Ravindra R
Sudha, Belgur S
Margankop, Sheetal B
Kattimani, Pramod P
Joshi, Shrinivas D
 
Subject 1,3,4-Oxadiazole
Anti-fungal activity
Anti-bacterial activity
1, 2, 4-Triazole
 
Description 1082-1096
1,2,4-Triazoles and 1,3,4-oxadiazoles independently are very important pharmacophores. In view of this, a new class of
1,2,4-triazole clubbed with 1,3,4-oxadiazole motifs have been prepared and characterized by IR, 1H NMR, 13C NMR and
mass spectral analysis. Molecular docking of all the title compounds into S. aureus tyrosyl-tRNA synthetase (PDB: 1JIJ) and
lanosterol 14α-demethylase complex with standard inhibitor Fluconazole (PDB: 3KHM) is performed which snugly fitted
into the active site thus explaining their excellent inhibitory activity exhibiting their possible antibacterial and antifungal
activity, respectively. Drug-likeliness, Drug score values and toxicity prediction analyses of all the title compounds have
shown favourable values and these molecules belong to Class 4 and Class 5 categories which make them useful scaffolds.
Interestingly, the compounds 7h, 7i, 7k, 7u and 7v have exhibited majestic antibacterial activity. Also, these compounds
have shown antifungal activity against all pathogenic fungal strains with lower MIC value ranging from 0.50 - 4.00 μg/mL.
 
Date 2022-10-21T04:54:59Z
2022-10-21T04:54:59Z
2022-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60721
https://doi.org/10.56042/ijc.v61i10.67206
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(10) [Oct 2022]