Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo [1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones
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Title |
Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo [1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones
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Creator |
Marri, Srinivas
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Subject |
6-Methyl-3-arylimidazolo[1,2-b]isoxazoles
1,3,5-Triazinane-2-thiones Trimolecular condensation Antibacterial activity Antifungal activity |
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Description |
1046-1053
Synthesis of novel 5-methyl-1-(4-(6-methylimidazo[1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones 6 has been achieved by the reaction of 3-amino-5-methylisoxazole 1 with p-nitrophenacyl bromide, followed by reduction of 3 with stannous chloride. Compounds 4 on treatment with different aryl isothiocyanates in refluxing benzene, followed by trimolecular condensation with 30% HCHO and methyl amine in ethanol affords the title compounds 6. The newly synthesized compounds 6 have been evaluated for their in vitro antimicrobial activity. Compounds 6 exhibit potent antimicrobial activity compared to that of standard drugs. |
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Date |
2022-10-21T05:57:27Z
2022-10-21T05:57:27Z 2022-10 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60725 https://doi.org/10.56042/ijc.v61i10.62377 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.61(10) [Oct 2022]
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