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Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo [1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones

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Title Synthesis and antimicrobial activity of novel 5-methyl-1-(4-(6-methylimidazo [1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones
 
Creator Marri, Srinivas
 
Subject 6-Methyl-3-arylimidazolo[1,2-b]isoxazoles
1,3,5-Triazinane-2-thiones
Trimolecular condensation
Antibacterial activity
Antifungal activity
 
Description 1046-1053
Synthesis of novel 5-methyl-1-(4-(6-methylimidazo[1,2-b]isoxazol-3-yl)phenyl)-3-aryl-1,3,5-triazinane-2-thiones 6 has
been achieved by the reaction of 3-amino-5-methylisoxazole 1 with p-nitrophenacyl bromide, followed by reduction of
3 with stannous chloride. Compounds 4 on treatment with different aryl isothiocyanates in refluxing benzene, followed by
trimolecular condensation with 30% HCHO and methyl amine in ethanol affords the title compounds 6. The newly
synthesized compounds 6 have been evaluated for their in vitro antimicrobial activity. Compounds 6 exhibit potent
antimicrobial activity compared to that of standard drugs.
 
Date 2022-10-21T05:57:27Z
2022-10-21T05:57:27Z
2022-10
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60725
https://doi.org/10.56042/ijc.v61i10.62377
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(10) [Oct 2022]