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Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision wound

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Title Statement Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision wound
 
Added Entry - Uncontrolled Name Kazak, Filiz ; Department of Biochemistry, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
Isik, Egemen
Yurtal, Ziya
Alakus, İbrahim
The study does not have any funding.
 
Uncontrolled Index Term Electroteraphy; Glucose-6-phosphate dehydrogenase; Malondialdehyde; M. gastrocnemius; M. quadriceps femoris
 
Summary, etc. Electrical stimulation (ES) are known to have beneficial effects in wound healing. However, the effect of electrical stimulation in wound theraphy on the oxidant and antioxidant levels of various tissues in the body remains unclear. Here, we investigated the effects of electrical stimulation on the oxidative stress capacity of tissues in a rat model with a surgical incision wound on the lateral line of the femoral region. Rats divided in two groups: control and ES group. A longitudinal skin incision was made only from the right lateral line of all rats. ES was applied 200 μs, 20 Hz, 2mA for 20 min during 15 days. Some oxidative stress parameters (malondialdehyde (MDA), reduced glutathione (rGSH), glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx) and catalase (CAT)) in tissues (brain, heart, kidney, liver, testis, gastrocnemius and quadriceps femoris muscle) were obtained spectrophotometrically. The ES reduced oxidative stress by decreasing MDA and simultaneously increasing different antioxidants in different tissues. The results suggest that incision wound could induce oxidative stress in tissues and electrical stimulation post-incision wound may have ameliorative effect.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-10-25 13:59:06
 
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http://op.niscair.res.in/index.php/IJEB/article/view/55921
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 11 (2022): IJEB [NOVEMBER 2022]
 
Language Note en