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<p>Antimicrobial Activities of some Synthesized Cyclo (N<sup>α</sup>-dinicotinoyl) [L-phenylalanyl-L-leucine] Pentapeptide Candidates</p>

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Title Statement <p>Antimicrobial Activities of some Synthesized Cyclo (N<sup>α</sup>-dinicotinoyl) [L-phenylalanyl-L-leucine] Pentapeptide Candidates</p>
 
Added Entry - Uncontrolled Name Amr, A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11451, Saudi Arabia Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12622, Egypt
Abdel-Megeid, R E; Photochemistry Department, National Research Center, Cairo, Dokki 12622, Egypt
Abd Elwahab, A A; Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12622, Egypt
Flefel, E M; Photochemistry Department, National Research Center, Cairo, Dokki 12622, Egypt
Elsayed, E A; Bioproducts Research Chair, Zoology Department, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki 12622, Egypt
 
Uncontrolled Index Term Antimicrobial agents; Linear dipeptide pyridine; Macrocyclic pentaazapyridine  
 
Summary, etc. <p>Some of cyclo (N<sup>α</sup>-di-nicotinoyl)[L-phenylalanyl-L-leucine]pentapeptides<strong>3-6</strong> has been synthesized starting from bis-(1-carboxy-2-substituted)-3,5-diaminocarbonyl)pyridine <strong>3</strong> and N,N-bis-(1-hydrazonyl-2-substituted)-3,5 diaminocarbonyl) pyridine <strong>2</strong>. Treatment of <strong>1</strong> or <strong>2</strong> afforded the corresponding bis-ester derivative <strong>3</strong>, which was hydrolyzed with sodium hydroxideto give bis-acid <strong>4</strong>. Cyclization of bis-acid <strong>4</strong> with L-dibasic amino acid methyl esters, afforded the corresponding macrocyclic methyl esters <strong>5a,b</strong>, respectively. Finally, hydrazonolysis of <strong>5a,b</strong> with hydrazine hydrated in refluxing methanol afforded macrocyclic pentapeptide hydrazides <strong>6a,b</strong>, respectively. Some of these compounds exhibited antimicrobial activities comparable with Chloramphenicol and Fusidic acid as reference drugs.</p>
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-11-09 07:52:48
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/JSIR/article/view/68178
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 79, ##issue.no## 1 (2020): Journal of Scientific & Industrial Research
 
Language Note en