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<p>Anti-proliferate Activity and 5α-reductase Inhibitors of Chiral Macrocyclic (Nα-di-nicotinoyl)[L-phenylalaninyl-L-leucinyl]Pentapeptide Candidates Against LNCaP and PC-3 Prostate Cancer Cell Lines</p>

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Title Statement <p>Anti-proliferate Activity and 5α-reductase Inhibitors of Chiral Macrocyclic (Nα-di-nicotinoyl)[L-phenylalaninyl-L-leucinyl]Pentapeptide Candidates Against LNCaP and PC-3 Prostate Cancer Cell Lines</p>
 
Added Entry - Uncontrolled Name Alanazi, M M; Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Amr, M A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11451, Saudi Arabia Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11451, Saudi Arabia
Naglah, A M; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11451, Saudi Arabia Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt
Mageid, R E Abdel; 5Photochemistry Department National Research Center, Dokki, Cairo, 12622, Egypt
Elsayed, E A; Photochemistry Department National Research Center, Dokki, Cairo, 12622, Egypt Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
 
Uncontrolled Index Term 5α-reductase inhibitors; Anti-proliferate activities; Macrocyclic pentapeptide, Schiff bases
 
Summary, etc. <p>A series of macrocyclic derivatives <strong>2-6</strong> were prepared using N<sup>α</sup>-dinicotinoyl-bis[L-phenylalaninyl-L-leucyl]hydrazide <strong>1</strong> and cyclo pentapeptide hydrazide <strong>2 </strong>as starting materials. The hydrazide <strong>1 </strong>was cyclized with diaminoalkanes to macrocyclic hezaazahexaamide derivatives <strong>3a-c</strong>, respectively. Finally, compound<strong>2</strong> was condensed with 3,5-diacetylpyridine gave the corresponding macrocyclic Schiff base <strong>4</strong>. Finally, condensation of <strong>2</strong> with substituted aromatic or heterocyclic aldehyde derivatives gave the corresponding Schiff base derivatives <strong>5a-f</strong> and <strong>6a-c</strong>, respectively. The synthesized compounds were screened as 5α-reductase inhibitors and anti-proliferative activity against prostate cancer cell lines.</p>
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-11-09 07:52:48
 
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http://op.niscair.res.in/index.php/JSIR/article/view/68142
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 79, ##issue.no## 1 (2020): Journal of Scientific & Industrial Research
 
Language Note en