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Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds

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Title Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds
 
Creator Kantar, Cihan
Baltaş, Nimet
Dereci, Oğuz Kağan
Şaşmaz, Selami
 
Subject Phthalonitrile
Azo dyes
Urease
Acetylcholinesterase
Enzyme inhibition
 
Description 1188-1193
Based on the relationship between Helicobacter pylori and Alzehimer’s disease, new azo phthalonitrile compounds
containing different amino pyridines have been synthesized. These compounds can inhibit both Urease and
Acetylcholinesterase, which are the most important enzymes in the treatment of Helicobacter pylori and Alzehimer’s
disease, respectively. All compounds have shown better inhibition than standards in the presence of both enzymes.
Especialy, azo phthalonitrile compound 4 is more active than other compounds and standards, showed a significant
inhibition performance and efficient IC50 values to Urease (20.47±0.14 μM) and Acetylcholinesterase (4.73±0.07 μM)
enzymes. Interestingly, the inhibitory effect of the newly synthesized compounds against to Urease and Acetylcholinesterase
is same ranking.
 
Date 2022-11-11T09:42:13Z
2022-11-11T09:42:13Z
2022-11
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60823
https://doi.org/10.56042/ijc.v61i11.68270
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(11) [Nov 2022]