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One pot synthesis of 4,5-dibromo-3,6-diarylpyridazine from 1,4-diarylbuta- 1,3-diyne

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Title One pot synthesis of 4,5-dibromo-3,6-diarylpyridazine from 1,4-diarylbuta- 1,3-diyne
 
Creator Shit, Prasenjit
Singha, Raju
 
Subject Diyne
NBS
Cyclization
One pot reaction
Pyridazine
 
Description 1159-1163
A one-pot two-step methodology has been developed for the synthesis of 4,5-dibromo-3,6-diarylpyridazines starting from easily available starting material 1,4-diarylbuta-1,3-diynes. The reaction goes through the electrophilic addition of Br+ ion with alkyne bonds followed by nucleophilic addition of hydrazine and intramolecular cyclization.
 
Date 2022-11-11T10:21:55Z
2022-11-11T10:21:55Z
2022-11
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60829
https://doi.org/10.56042/ijc.v61i11.63897
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(11) [Nov 2022]