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<p class="Default"><strong>One pot synthesis of 4,5-dibromo-3,6-diarylpyridazine from 1,4-diarylbuta-1,3-diyne</strong></p>

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Title Statement <p class="Default"><strong>One pot synthesis of 4,5-dibromo-3,6-diarylpyridazine from 1,4-diarylbuta-1,3-diyne</strong></p>
 
Added Entry - Uncontrolled Name SINGHA, RAJU ; Panskura Banamali College (Autonomous)
Shit, Prasenjit ; Panskura Banamali College
DST-SERB, Government of India for financial support of this project (File No.: ECR/2017/000396
 
Uncontrolled Index Term Organic Reaction Methodology
Diyne, NBS, Cyclization, one pot reaction, Pyridazine
 
Summary, etc. Pyridazines are an important scaffold present in various pharmacophores due to their significant physiochemical features of drug molecules. Laboratory synthesis of pyridazines is highly important because their natural sources are very rare. A one-pot two-step methodology has been developed for the synthesis of 4,5-dibromo-3,6-diarylpyridazines starting from easily available starting material 1,4-diarylbuta-1,3-diynes. The reaction goes through the electrophilic addition of Br<sup>+</sup> ion with alkyne bonds followed by nucleophilic addition of hydrazine and then intramolecular cyclization.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-11-14 15:22:20
 
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application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/63897
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 11 (2022): Indian Journal of Chemistry-(IJC)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJC/article/download/63897/465611597
http://op.niscair.res.in/index.php/IJC/article/download/63897/465611600
http://op.niscair.res.in/index.php/IJC/article/download/63897/465611601