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<p>Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds</p>

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Title Statement <p>Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds</p>
 
Added Entry - Uncontrolled Name Kantar, Cihan ; Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Chemistry, Rize, Turkey
Baltaş, Nimet ; Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Chemistry, Rize, Turkey
Dereci, Oğuz Kağan; Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Chemistry, Rize, Turkey
Şaşmaz, Selami ; Recep Tayyip Erdogan University, Faculty of Arts and Sciences, Department of Chemistry, Rize, Turkey
 
Uncontrolled Index Term Phthalonitrile, Azo dyes, Urease, Acetylcholinesterase, Enzyme inhibition
 
Summary, etc. <p style="text-align: justify;">Based on the relationship between <em>Helicobacter pylori</em> and Alzehimer’s disease, new azo phthalonitrile compounds containing different amino pyridines have been synthesized. These compounds can inhibit both Urease and Acetylcholinesterase, which are the most important enzymes in the treatment of <em>Helicobacter pylori</em> and Alzehimer’s disease, respectively. All compounds have shown better inhibition than standards in the presence of both enzymes. Especialy, azo phthalonitrile compound <strong>4</strong> is more active than other compounds and standards, showed a significant inhibition performance and efficient IC<sub>50</sub> values to Urease (20.47±0.14 µM) and Acetylcholinesterase (4.73±0.07 µM) enzymes. Interestingly, the inhibitory effect of the newly synthesized compounds against to Urease and Acetylcholinesterase is same ranking.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-11-14 15:22:20
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/68270
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 11 (2022): Indian Journal of Chemistry-(IJC)
 
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