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Effect of butylphthalide combined with ozagrel sodium on cerebral perfusion and oxidative stress indexes in patients with transient ischemic attack

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Title Effect of butylphthalide combined with ozagrel sodium on cerebral perfusion and oxidative stress indexes in patients with transient ischemic attack
 
Creator Gong, Ping
Li, Na
 
Subject Butylphthalide
Sodium ozagrel
Transient ischemic attack
Oxidative stress
Plaque
 
Description 788-792
This study has been undertaken to evaluate the effect of butylphthalide combined with ozagrel sodium on cerebral
perfusion and oxidative stress indexes in patients with transient ischemic attack. In this study, a total of 116 patients
diagnosed as transient ischemic attack in our hospital (February 2018-February 2020) have been selected and divided into
two groups according to the treatment methods.58 cases in the control group have been treated with ozagrel sodium,
58 cases in the observation group have been treated with butylphthalide combined with ozagrelsodium. The CT perfusion
imaging parameters, oxidative stress indexes, plaque area, and the levels of platelet activating factor (PAF), α-granule
membrane protein-140 (GMP-140), fibrinogen (FIB), platelet aggregation rate (PAgT), neuron-specific enolase (NSE),
oxygen-inducible factor-1α ( HIF-1α ), and matrix metalloproteinases-9 ( MMP-9) in the two groups have been recorded,
and the total effective rate and adverse reaction rate have been counted. The results shown that the total effective rate of the
observation group is higher than that of the control group, and the difference is statistically significant (χ2 = 4.640,
P = 0.031). The average time (MTT) required for the two groups of contrast agents to pass through the local brain tissue and
the time (TTP) required starting the injection of contrast agents to reach the peak concentration decreased compared to that
with before treatment. After treatment, the MTT and TTP of the observation group are shorter than those of the control
group (P < 0.05). Compared with before treatment, superoxide dismutase (SOD) in the two groups has higher than that in
the control group, PAF, GMP-140, FIB, PAgT, NSE, HIF-1α, MMP-9, malondialdehyde (MDA) and plaque area has
decreased. After treatment, the levels of related factors in the observation group are better than those in the control group,
and the plaque area is less than that in the control group (P < 0.05).There has been no significant difference in the adverse
reaction rate between the observation group and the control group (χ2 = 0.438, P = 0.508).
 
Date 2022-11-18T10:04:17Z
2022-11-18T10:04:17Z
2022-11
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/60835
https://doi.org/10.56042/ijct.v29i6.67424
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.29(6) [November 2022]