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Effect of Yupingfeng granule assisted fluticasone propionate nasal spray on patients with AR and its regulation on IL-5, ICAM-1 and ECP

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Title Effect of Yupingfeng granule assisted fluticasone propionate nasal spray on patients with AR and its regulation on IL-5, ICAM-1 and ECP
 
Creator She, Xiumei
Qiao, Yanming
Fan, Yuling
Yuan, Qian
Bai, Yunyun
 
Subject Allergic rhinitis
Fluticasone propionate
Immunomodulation
TCM
Yupingfeng granules
 
Description 776-781
The present investigation deals with the effect and mechanism of Yupingfeng granule assisted Fluticasone propionate nasal
spray in the treatment of patients with allergic rhinitis (AR). Total of 140 patients with AR treated in Yulin Hospital of Traditional
Chinese Medicine from December 2019 to July 2020 have been selected for clinical trial. The patients in traditional Chinese
medicine (TCM) group were treated with Yupingfeng granule plus Fluticasone propionate nasal spray, while those in routine group
are treated with Fluticasone propionate nasal spray. The remaining basic treatment in the two groups remained the same, with
60 patients in each group. Symptom, sign score, TCM syndrome score, quality of life score, interleukin-5 (IL-5), intercellular
adhesion molecule-1 (ICAM-1), eosinophil cationic protein (ECP) levels in peripheral blood and clinical treatment effect have been
compared between two groups before and after treatment. Before treatment, there is no significant difference in the scores of
symptoms, signs and total scores between the two groups; after treatment, these were lower than those of the routine group. There is
no significant difference in the scores of TCM symptoms between the two groups (P> 0.05) before treatment, while after treatment;
these are lower than those of the routine group. The levels of IL-5, ICAM-1 and ECP in the peripheral blood of the patients in the
two groups have been compared, and there is no significant difference between the two groups before treatment while after
treatment, the levels of IL-5 and ECP in the peripheral blood of the patients in TCM group were lower than those in the routine
group, and the difference had statistical significance. Yupingfeng granule assisted Fluticasone oropionate nasal spray can
effectively relieve the clinical symptoms of patients with AR, improve the quality of life, regulate the levels of IL-5 and ECP in
peripheral blood and improve the clinical effect.
 
Date 2022-11-18T10:14:33Z
2022-11-18T10:14:33Z
2022-11
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/60837
https://doi.org/10.56042/ijct.v29i6.67389
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.29(6) [November 2022]