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Preparation and characterization of hybrid nanofibrous polymer scaffolds for tissue engineering applications

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Title Preparation and characterization of hybrid nanofibrous polymer scaffolds for tissue engineering applications
 
Creator Ramar, Gurumoorthi
Ashokumar, Sangeetha
Periyasamy, Bhuvana K
Bensingh, R Joseph
 
Subject Bone tissue engineering
Chitosan
Electrospinning
Silver
Sodium alginate
 
Description 706-712
This paper endeavours towards the scientific study of infusion of silver nanoparticles (Ag NPs) into biodegradable polymer
scaffold for bone tissue engineering. Highly biocompatible Ag NPs have been synthesized using chitosan as stabilizing and
reducing agent. The synthesized Ag NPs have been uniformly suspended in polyvinyl alcohol (PVA) and sodium alginate (SA)
solution and nanofibrous mat like scaffolds have been fabricated using electrospinning process. The proposed process of
infusing Ag NPs in PVA/SA medium resulted in nanofibers of smaller diameter and reduced pore size resulted in high surface
area which is due to electrostatic charge interaction of Ag NPs during electrospinning. Thus, the improved surface area has
facilitated better growth of extracellular matrix (ECM) compared to traditional coating method. The effect of coating
nanoparticles on prepared polymeric scaffolds proves less than infusion of nanoparticles prior to electrospinning.
 
Date 2022-11-18T11:31:26Z
2022-11-18T11:31:26Z
2022-11
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/60845
https://doi.org/10.56042/ijct.v29i6.67353
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.29(6) [November 2022]