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<p>Antiproliferative Activities of Cyclo (<em>N<sup>α</sup></em>-pyrido)-bis-[(L-valinyl)-L-ornithine] and its <em>in vitro</em> anti-VEGFR-2 Inhibition</p>

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Title Statement <p>Antiproliferative Activities of Cyclo (<em>N<sup>α</sup></em>-pyrido)-bis-[(L-valinyl)-L-ornithine] and its <em>in vitro</em> anti-VEGFR-2 Inhibition</p>
 
Added Entry - Uncontrolled Name Amr, A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia. Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12 622, Egypt.
Elsayed, E A; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia Natural and Microbial Products Department, National Research Centre, Dokki, Cairo 12 311, Egypt
Almehizia, A A; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia.
Wadaan, M A; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia
Sabry, Nermien M; Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12 622, Egypt.
Baabbad, A ; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia
 
Uncontrolled Index Term Amino acid ester, Anticancer, Cyclic tripeptide, in vivo, Kinase inhibition, Macrocyclic
 
Summary, etc. <p>Research is continuing for synthesizing new molecules with potent pharmacological effects against cancer. In the current work we prepared a new tripeptide and investigated its <em>in vitro</em> as well as <em>in vivo</em> antiproliferative effects. Firstly, cyclo (<em>N<sup>α</sup></em>-pyrido)-bis-[(L-valinyl)-L-ornithine] was prepared and then tested against 17 different cancer cell lines. Results showed that the prepared compound showed increased cytotoxic effects (in terms of decreased IC50 value), which reached about 20.3, 28.1, 18.3 and 72.3% against RKOP27, K561, GOTO, HT1080 cell lines, respectively, in comparison to standard positive controls. Furthermore, cancer cell viability was probably affected through VEGFR-2 kinase inhibition.</p>
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-11-19 07:20:43
 
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http://op.niscair.res.in/index.php/JSIR/article/view/68683
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 79, ##issue.no## 4 (2020): Journal of Scientific & Industrial Research
 
Language Note en