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<p>Investigation of Growth Inhibitory Effects of cyclo (<em>N<sup>α</sup></em>-pyrido)-bis-[(L-valinyl)-L-ornthenyl acid hydrazide] on Various Cancer Cells as well as i<em>n vitro</em> VEGFR-2 Kinase Inhibition</p>

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Title Statement <p>Investigation of Growth Inhibitory Effects of cyclo (<em>N<sup>α</sup></em>-pyrido)-bis-[(L-valinyl)-L-ornthenyl acid hydrazide] on Various Cancer Cells as well as i<em>n vitro</em> VEGFR-2 Kinase Inhibition</p>
 
Added Entry - Uncontrolled Name Amr, A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia. Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12 622, Egypt.
Elsayed, E A; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia Natural and Microbial Products Department, National Research Centre, Dokki, Cairo 12 311, Egypt
Al-Omar, M A; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia.
El-Enshasy, H A; Institute of Bioproduct Development, Universiti Teknologi, Malasiya 81 310, skudai Johor, Malasiya City of Scientific Research and Technology Applications (CSAT) New Burg Al Arab Alexandria, Egypt
 
Uncontrolled Index Term Azide method, Cell lines, In vitro, In vivo, Kinase activity, Macrocyclic tripeptidopyridine
 
Summary, etc. <p class="Abstract"><span lang="EN-GB">During the current work, we synthesized a new peptide derivative; 4,13-diisopropyl-2,5,12,15-tetraoxo-3,6,11,14-tetraaza-1(3,5)-pyridinacyclopentadecaphane-7-carbohydrazide. The prepared hydrazide was investigated for its <em>in vivo</em> as well as <em>in vitro</em> anticancer effects. Results revealed that this derivative has a great potential against 6 cancerous cell lines. Furthermore, the highest effect was obtained against HT1080 and HeLa cells, where the compound showed 7.4- and 15.1-folds increased activity against them, respectively. Additionally, the compound seems to exert its potential anticancer effect by affecting the kinase enzyme VEGFR-2. Finally, the compound showed promising results when tested in <em>in vivo</em> against prostate cancer developed animal models.</span></p><br />
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-11-19 07:20:43
 
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http://op.niscair.res.in/index.php/JSIR/article/view/68682
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 79, ##issue.no## 4 (2020): Journal of Scientific & Industrial Research
 
Language Note en