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<p>Cyclo (<em>N<sup>α</sup></em>-dinicotinoyl)-bis-[(L-valinyl)-L-lysinyl acid hydrazide]: Assessment of its Role in Cancer and Kinase Activity Inhibition</p>

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Title Statement <p>Cyclo (<em>N<sup>α</sup></em>-dinicotinoyl)-bis-[(L-valinyl)-L-lysinyl acid hydrazide]: Assessment of its Role in Cancer and Kinase Activity Inhibition</p>
 
Added Entry - Uncontrolled Name Amr, A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia. Applied Organic Chemistry Department, National Research Center, Cairo, Dokki 12 622, Egypt.
Elsayed, E A; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia Natural and Microbial Products Department, National Research Centre, Dokki, Cairo 12 311, Egypt
Al-Omar, M A; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia.
Almehizia, A A; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia.
Abdel-Mageid, Randa E.; 5Photochemistry Department, National Research Center, Cairo, Dokki 12 622, Egypt.
 
Uncontrolled Index Term Anticancer, Hydrazide, Mechanism of action, Peptides, Synthesis
 
Summary, etc. <p class="Abstract">Current research aimed at evaluating the <em>in vitro</em> as well as i<em>n vivo</em> anticancer activities of a newly synthesized <br /> peptide hydrazide; i.e. 4,14-diisopropyl-2,5,13,16-tetraoxo-3,6,12,15-tetraaza-1(3,5)-pyridinacyclohexadecaphane-7-carbohydrazide. The hydrazide was synthesized from methyl 4,14-diisopropyl-2,5,13,16-tetraoxo-3,6,12,15-tetraaza-1(3,5)-pyridinacyclohexadecaphane-7-carboxylate <strong>2 </strong>by acting of hydrazine hydrate. It showed significant anticancer effects against different tested cell lines, where cervical, breast, liver, colon, prostate, brain, fibrosarcoma, leukemia and melanoma cell lines were the most affected cell types. The prepared derivative also inhibited VEGF-2 kinase enzyme significantly and exhibited an <em>in vivo</em> tumorigenic effects in mice model.<strong></strong></p>
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-11-19 07:20:43
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/JSIR/article/view/68669
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 79, ##issue.no## 4 (2020): Journal of Scientific & Industrial Research
 
Language Note en