Record Details

<strong>Efficacy and survival analysis of apatinib combined with capecitabine chemotherapy for second-line treatment of advanced esophageal cancer</strong>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <strong>Efficacy and survival analysis of apatinib combined with capecitabine chemotherapy for second-line treatment of advanced esophageal cancer</strong>
 
Added Entry - Uncontrolled Name Xu, Jinfa ; First Ward, Department of Oncology, The People’s Hospital of Chizhou, Chizhou 247 000, Anhui Province, China
Cai, Qing ; First Ward, Department of Oncology, The People’s Hospital of Chizhou, Chizhou 247 000, Anhui Province, China
Zhang, Xiufang ; First Ward, Department of Oncology, The People’s Hospital of Chizhou, Chizhou 247 000, Anhui Province, China
Zhang, Jianhua ; First Ward, Department of Oncology, The People’s Hospital of Chizhou, Chizhou 247 000, Anhui Province, China
 
Uncontrolled Index Term Advanced esophageal cancer; Apatinib; Capecitabine; Chemotherapy; Efficacy; Survival
 
Summary, etc. <p><span>This study explore the efficacy, toxic and side effects and survival impact of apatinib combined with capecitabine chemotherapy for the second-line treatment of advanced esophageal cancer. The clinical data of 76 patients with advanced esophageal cancer treated from January 2015 to April 2020 have been retrospectively analyzed. They are divided into experimental and control groups according to different treatment methods. The experimental group (n=29) underwent oral apatinib targeted therapy (250 mg/once/d) combined with oral capecitabine chemotherapy (1000 mg/m2 according to the body surface area on D1-14). Maintenance therapy with apatinib has been conducted after 4-6 cycles. The control group (n=47) received the second-line chemotherapy. After more than 2 cycles of chemotherapy, complete response is achieved in 0 cases, partial response in 19 cases, stable disease in 6 cases, and progressive disease in 3 cases. Overall response rate (ORR) is found to be 67.86% and the disease control rate is 89.28%. The median progression-free survival (mPFS) and the median overall survival (mOS) are 6.7 months and 8.9 months, respectively. Karnofsky Performance Status score of 2 points, liver metastasis, elevation of tumor marker squamous cell carcinoma and unsatisfactory efficacy are independent prognostic factors. In control group, ORR was 34.04%, and mPFS and mOS are 3.9 months and 7.4 months, respectively. No severe drug-related toxic and side effects have been observed, except for 1 patient who voluntarily discontinued treatment due to grade III hypertension. Apatinib combined with capecitabine chemotherapy shows good overall efficacy with satisfactory safety and tolerance for the second-line treatment of advanced esophageal cancer.</span></p>
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2022-11-22 10:22:41
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCT/article/view/67385
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 29, ##issue.no## 6 (2022): Indian Journal of Chemical Technology
 
Language Note en