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<p>Pharmacokinetic interaction potential assessment of cladrin, a potent bioactive constituent of <em>Butea monosperma,</em> and raloxifene, a prescription anti-osteoporotic by <em>in vitro</em> ADME approach</p><br />

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Title Statement <p>Pharmacokinetic interaction potential assessment of cladrin, a potent bioactive constituent of <em>Butea monosperma,</em> and raloxifene, a prescription anti-osteoporotic by <em>in vitro</em> ADME approach</p><br />
 
Added Entry - Uncontrolled Name Chauhan, Divya ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Sultana, Nazneen ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Yadav, Pavan K; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Rashid, Mamunur ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Husain, Athar ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Agarwal, Arun ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Chaturvedi, Swati ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Singh, Sandeep ; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Chourasia, Manish K; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Gayen, Jiaur R; Division of Pharmaceutics and Pharmacokinetic, CSIR-Central Drug Research Institute, Lucknow 226 031, India
Wahajuddin, Wahajuddin ; Pharmaceutics & Pharmacokinetics CSIR-Central Drug Research Institute, Lucknow
 
Uncontrolled Index Term Cladrin, Flavonoids, Herb-Drug interaction, Pharmacokinetics, Raloxifene, SPIP
 
Summary, etc. <p>Raloxifene is a well-known modulator of estrogen receptors which is structurally similar to tamoxifen. As flavonoids can interact with the estrogen modulator raloxifene <em>in vitro</em>, we performed an <em>in vitro</em> stability study and <em>in situ</em> permeability assay of raloxifene and cladrin in female Sprague-Dawley rats when administered alone and when co-administered. The <em>in vitro</em> study samples were analyzed by HPLC; raloxifene administered individually and in combination with cladrin was compared. In this study, we investigated the absorption, metabolic stability, plasma stability, determination of permeability and plasma protein binding of both drugs in SD rats using an established <em>in situ</em> single pass intestinal perfusion model. Increase in the bioavailability of raloxifene and cladrin alone or in co-administration also could be because of the activation of P-glycoprotein in the rat intestine. Further the present report concludes on the basis of ATPase assay of both raloxifene and cladrin alone and in combination showed that both drugs are P-gp substrate. In <em>in situ</em> permeability assay showed that the both drugs competitively lower the permeability of each other but still the predicted human permeability value lied in the range of high permeability drug.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2022-11-28 15:11:21
 
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http://op.niscair.res.in/index.php/IJTK/article/view/55946
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 21, ##issue.no## 4 (2022): Indian Journal of Traditional Knowledge
 
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