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| Field | Value |
| Title | Dissolved core alginate microspheres as "Smart-Tattoo" glucose sensors |
| Names |
CHAUDHARY, A
RAINA, M MCSHANE, MJ SRIVASTAVA, R |
| Date Issued | 2009 (iso8601) |
| Abstract | The feasibility of multilayer thin film coated dissolved-core alginate-templated microsphere sensors based on fluorescence resonance energy transfer and competitive binding, was explored in simulated interstitial fluid, using glucose as a model analyte. The glucose sensitivity was observed to be 0.89%/mM glucose with a linear response in the range of 0-50mM glucose. The sensor response was observed to be completely reversible in nature with a response time of 120 seconds. The system was further demonstrated to respond similarly using near-infrared dyes (Alexa Fluor-647-labeled dextran as donor and QSY-21-conjugated apo-GOx as acceptor) which exhibited a sensitivity of 0.94%/mM glucose with a linear response in range of 0-50mM glucose, making the sensor more amenable to in vivo use, when implanted in scattering tissue. |
| Genre | Proceedings Paper |
| Topic | Affinity Sensor |
| Identifier | EMBC: 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20,4098-4101 |