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Synthesis of iron nanoparticles, its characterization and anti-microbial activity assessment

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Title Synthesis of iron nanoparticles, its characterization and anti-microbial activity assessment
 
Creator Sawarn, Ayush
Singh, Priyanka
Dangi, Kapil
Yadav, Pooja
Verma, Anita Kamra
 
Subject Bacterial genotoxicity
Co-precipitation method
Growth kinetics
Kirby-Bauer method
Polyol method
Zone of inhibition
 
Description 1184-1189
We reported the efficacy of the Iron nanoparticles (IONPs) and assessed two different approaches for the synthesis of
IONPs i.e. Polyol and co-precipitation method and further, evaluate their antimicrobial properties. Ferrous sulphate
heptahydrate salts were reduced with ethylene glycol to obtain IONP and Fe+2 and Fe+3 iron precursor salts were used for
co-precipitation reaction that was performed with KOH at optimum heating. Further, synthesized (IONPs) were
characterized by hydrodynamic radii measurement done by DLS clearly indicating the size of IONPs is 79.75 nm in polyol
based and 135.1 nm in co-precipitation method. The biological efficacy in terms of antimicrobial activity was assessed by the
Kirby Bauer method, applied for both Gram-positive and Gram-negative bacteria such as Staphylococcus aureus and
Escherichia coli, respectively. The ZOI values i.e. Zone of inhibition diameter was found to be clearly visible in both S. aureus
and E. coli, indicating bactericidal activity. Further growth kinetics studies and bacterial genotoxicity was also assessed. Hence,
IONPs synthesized are proposed to have great potential as an antibacterial agent and can be used in drug delivery.
 
Date 2022-11-30T11:29:28Z
2022-11-30T11:29:28Z
2022-11
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60974
https://doi.org/10.56042/ijbb.v59i12.67294
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(12) [December 2022]