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Nanotechnology in vaccine and immunology

NOPR - NISCAIR Online Periodicals Repository

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Field Value
 
Title Nanotechnology in vaccine and immunology
 
Creator Sonali
Rawat, Amisha
Yadav, Monika
 
Subject Immunization
Nanoparticles
Nanotechnology
Vaccine
 
Description 1135-1143
Nanotechnology exploits the exclusive characteristics of nanoparticles with size ranging from 1 to 1000 nanometers
(nm). Various nanoparticles have presented magnificent potential for the fabrication of new drug carriers and vaccines. For
designing vaccine significant attempts are done to engineer novel vaccines and to increase the efficiency of current vaccines
for particular diseases. So far, few vaccines are engineered from killed pathogens or protein sub-units, while various
vaccines are founded on live-inactivated pathogens that holds the danger of retrieval of their pathogenicity under some
immune-compromised circumstances. To circumvent this designing of risk-free effectual vaccines in combination with
satisfactory carrier systems are reflected as a vital requirement to attain preferred humoral and cellular immunity for various
diseases. In the past years, utilization of vaccines based on nanoparticle has gained a pronounced responsiveness to increase
aimed delivery, immunization approaches and vaccine effectiveness to attain preferred immune retorts at the cell level. To
increase vaccine efficiency these nanoparticles mustguard the antigens from early proteolytic disintegration, controlled
release, enable antigen internalization and management by antigen presenting cells for harmless human usage. Nanoparticles
comprised of polymers, lipids, metals and proteins have previously been exploited to achievefew of these characteristics. In
this context, various physicochemical characteristics of nanoparticles have a crucial part in the establishment of vaccine
efficiency. This review emphases on the usage of nanoparticles centred vaccine and the importance of characteristics of
nanoparticles to achieve effective vaccines delivery in order to prompt preferred host immunity against various diseases.
 
Date 2022-11-30T11:46:32Z
2022-11-30T11:46:32Z
2022-11
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60982
https://doi.org/10.56042/ijbb.v59i12.67290
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(12) [December 2022]