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Antitumor impact of amygdalin on adaptive immune response in BALB/c mice with breast cancer

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Title Statement Antitumor impact of amygdalin on adaptive immune response in BALB/c mice with breast cancer
 
Added Entry - Uncontrolled Name Yavari, Aboolfazl ; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Zare, Fateme ; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Dashti, Fateme ; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Valizadeh, Hamideh ; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fesahat, Farzaneh ; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Dehghan Manshadi, Mahdi Dehghan; Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
 
Uncontrolled Index Term Apoptosis; Granzyme B; Tumor growth
 
Summary, etc. <p style="text-align: justify;">Amygdalin is a potential therapeutically target in cancer. The main purpose of this experimental study was to evaluate the therapeutic effect of amygdalin in the mice model of breast cancer. The percentages of CD4, CD8 T lymphocyte, intracellular IFN-γ, and Granzyme B were assessed in spleen cells of tumorized mice treated with 50 and 150 mg/kg of amygdalin (AG<sub>50</sub> and AG<sub>150</sub>). The expression of <em>caspase 3</em> and <em>p53</em>, tumor size, and survival rate of Balb/c mice was determined in tumor tissue after amygdalin administration. No significant difference was observed in the frequency of CD4+ and CD8+ T cells in the three study groups. However, a significantly increased level of granzyme B in CD8+ T cells, as well as a significant decrease in the level of IL-10 in CD4+ T cells was detected in the AG<sub>50</sub> group compared to the AG<sub>150</sub>. There was no significant difference in the expression of <em>caspase 3</em> and <em>P53</em> between the two groups. A significant change was seen in tumor size and survival rate of AG<sub>50</sub> and AG<sub>150</sub> groups compared to the controls. Our findings indicated that antitumor effect of amygdalin in vivo was probably due to stimulating the effective immune response, not apoptotic genes induction.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-12-01 10:08:04
 
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http://op.niscair.res.in/index.php/IJEB/article/view/56791
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 12 (2022): IJEB [DECEMBER 2022]
 
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